The series takes place in and around the town of Crystal Cove, self-proclaimed as the "Most Hauntedest Place on Earth" and its abundance of ghost and monsters provide most of the town’s revenue with tourist dollars. This often results in the Scooby Gang butting heads with Mayor Fred Jones Sr. (Gary Cole) and Sheriff Bronson Stone (Patrick Warburton) as their exposing of the various supernatural threats as nothing more than criminals in masks is considered bad for the town’s tourist based economy, made more awkward by the Mayor being our lovable Fred's dad.
• Don Knotts as a random tourist is a nod to The New Scooby-Doo Movies.
• Casey Kasem who originally voiced Shaggy now voices Shaggy’s dad.
• Linda Cardellini who played Velma in the live action movies plays Velma’s friend Hotdog Water.
The element that may catch fans by surprise is that Scooby-Doo! Mystery Incorporated takes the show into a serial format, not something done any of the previous incarnations, with an ongoing story arc that will track a larger mystery across the two seasons, and though it does still incorporate the “monster of the week” elements we've come to now and love, along with some nice tongue-in-cheek references to the formulaic nature of the older versions, it is a show that rewards viewer for tuning in each and every week as more clues are uncovered.
Yet it’s not just the serial format that makes this version stand out from previous incarnations it's the time the show spends letting us get to know our main characters, in ways we’ve never seen before. No longer are they just two dimensional characters with one simple defining character trait, instead they are fully fleshed out and even given time to change and grow over the course of the two seasons. The show starts with Fred (Frank Welker) as a trap obsessed mess who deeply wants to impress his emotional distant father while also being completely oblivious to the fact that Daphne (Grey DeLisle) is madly in love with him, but overtime he will learn what is truly important in his life. Meanwhile Daphne herself is insecure about being overshadowed by her overly successful sisters and Fred’s failure to see her other than a friend slowly drives her around the bend. Velma (Mindy Cohn) is still the chief brains behind the groups mystery solving ability but in what could come as a bit surprise to many a fan is that the show opens with her and Shaggy (Matthew Lillard) in a relationship, though it’s a secret one because Shaggy is afraid of Scooby (Frank Welker) being jealous.
Who could have seen this coming?In these two seasons the group’s dynamic goes through some serious emotional turbulence that becomes the backbone of the series; we actually care if Fred and Daphne eventually hook and the idea that Shaggy could ever pick a woman over Man’s Best Friend is treated somewhat seriously. Of course the show isn’t an animated version of Beverly Hills 90210 as our heroes will often have to put their own personal issues aside to tackle whatever “supernatural” threat has reared its ugly masked head that week.
It's the over arcing plot of the much bigger mystery that is the centerpiece to this series for in between exposing various residence and visitors as masked monster the gang receives cryptic messages from someone known simply as Mister E (Lewis Black), a shadowy figure who parcels out information that will not only reveal a mystery about a fabulous cursed treasure of immense value but also knowledge of four students and their bird Professor Pericles (Udo Kier) who formed a high school mystery solving club called Mystery Incorporated, a group that just so happened to disappear twenty years ago while hunting down that very same cursed treasure mystery.